Endocrine Abstracts

This 32 year old lady was referred in 2008 with Graves Disease. She presented with typical symptoms which included tiredness, shaking, palpitations, itching, eye redness, opthalmopathy, and exopthalmos. She had lost 3 stones over 3 months at Weight watchers. The GP had commenced carbimazole but she did not know the dose. In September 2008 results showed FT4 73.6, TT3 >12.5, TSH <0.05 and +TPO antibodies – >1300. This lady declined a referral to the ophthalmolo...

It is important to identify whether benign adrenal incidentalomas are hormonally active. Traditionally, investigations were arranged during the first medical consultation and relied heavily on the patient remembering a considerable number of instructions. The patient was required to collect urine bottles from pathology, a prescription from pharmacy and perform multiple tests including renin, which was often incorrectly performed in outpatients. Due to the cumbersome nature of ...

Hypopituitarism is associated with increased cardiovascular mortality. It has been suggested that hypogonadism, hypothyroidism, growth hormone deficiency (GHD), or indeed unphysiological hormone replacement regimens, might contribute to this excess cardiovascular risk. The adverse effect of hypercortisolaemia on insulin resistance, carbohydrate metabolism and hypertension is well recognised. It is also known that glucocorticoids adversely affect the coagulation-fibrinolytic sy...